A brief talk on the Xanthohumol

  • A special substance in hops called Xanthohumol has attracted more and more people's attention. It belongs to isopentene flavonoids (Xantho-humol, referred to as Xn). Scientists have shown that Xanthohumol has obvious anti-cancer effects.

    The Xanthohumol is a kind of biocatalyst, which has an anticancer effect. The anticancer effect of xanthohumol is mainly manifested in the following aspects: Firstly, xanthohumol can prevent cancer by regulating the pathway of tumor formation. In the process of transforming carcinogenic precursors into carcinogens. Some inducible enzymes play a role. Studies on xanthohumol have shown that xanthohumol inhibits the early growth of cancer cells mainly by inhibiting the enzyme activity. So as to achieve effective prevention of cancer. Secondly, it can inhibit the proliferation of cancer cells. In vitro experiments with human breast, colon and ovarian cancers, xanthohumol showed antiproliferative activity in cancer cell lines. Miranda et al. Used 6 kinds of flavonoids, such as fulvin, to inhibit the proliferation of some cancer cells in vitro. The results showed that xanthohumol could inhibit the proliferation of these cancer cells, and some cancer cells were tested in vitro.

    The results showed that xanthohumol could inhibit the proliferation of these cancer cells, and the inhibitory effect was stronger than that of other six flavonoids. In addition, the inhibition concentration of fulvic also increases with the prolongation of cell proliferation time. Further studies have shown that the mechanism of xanthohumol inhibiting the proliferation of cancer cells is that xanthohumol inhibits the synthesis of cancer cell DNA, making it unable to replicate and express. It has no effect on the growth and reproduction of normal cells.

    With the in-depth study of the pharmacological activities of xanthohumol, people have found the importance of xanthohumol. As a drug and food additive, xanthohumol has attracted more and more attention. So the industrial enzyme production of fulvic is inevitable. Because xanthohumol is unique in hops, it is very difficult to get xanthohumol from hops. Many experts are committed to isolating xanthohumol from hops.

    In addition, fulvic also has phytoestrogenic effect, which can improve the symptoms of menopause. The latest results show that fulvic can inhibit HIV-1 effectively, and may be used as a precursor compound. It may become a new chemotherapeutic agent for HIV-1 infectious diseases. Fulvic can effectively inhibit the replication of falciparum malaria and the pathogen of malaria. Xanthohumol has a long study process in the enzymology history. In Chinese medicine, hops are used to treat all kinds of ailments. High concentration of fulvic in beer may be the reason why epidemiological observation shows that drinking beer often is good for health. Xanthohumol has a variety of pharmacological effects, including antioxidant, cardiovascular protection, anti-cancer, cancer chemoprevention, anti-viral, anti-obesity and anti-inflammation.

    Because Xanthohumols are becoming healthier and present only in hops, drinking beer is currently the only source of Xanthohumols. Brewers want to increase the intake of xanthohumol by increasing the amount of xanthohumol in beer. However, for xanthohumol in beer to be antioxidant and anticancer, one needs to drink 118 gallons (450 litres) of beer a day! Therefore, researchers hope to be able to extract xanthohumol from hops, and then make tablets for cancer prevention and anti-cancer use.

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