What is Polygalic acid?

  • Polygalic acid has a strong sputum effect; it has an inhibitory effect on cyclic adenosine phosphate diterpene enzyme; it can enhance the body's physical strength and intelligence; it has a strong hemolysis effect and has an inhibitory effect on aldosterone reductase. In addition, there are anti-mutation, anti-cancer, sedative, anti-convulsion, anti-edema and diuretic effects.


    Content determination


    High performance liquid chromatography

    Chromatographic conditions and system suitability test: column is Calisil ODS-100 column (250mm × 4.6mm, 5μm), with octadecylsilane bonded silica as a filler; methanol -0.2% phosphoric acid solution (70:30) is the mobile phase; the detection wavelength is 210 nm. The theoretical plate number should be no less than 2,500 according to the peak value of the topois acid. Preparation of the test solution: Take about 1 gram of the powder of this product (passing the No. 4 sieve), accurately weigh it, place it in the Soxhlet extractor, add appropriate amount of methanol, immerse for 30 minutes, heat and reflux for 5 hours, and evaporate the extract. The residue was added with 20 ml of 10% hydrochloric acid solution, dissolved by micro-heating, hydrolyzed in a water bath for 2 hours, taken out, allowed to cool, filtered, and the precipitate was washed with water until neutral. The residue was dissolved in methanol and transferred to a 100 ml volumetric flask, diluted with methanol. Scale, shake well, that is.


    Thin layer scanning

    Shimadzu CS-930 thin layer scanner; DR-2 type data processor; quantitative capillary (Dranmond); silica gel G plate; developing agent: chloroform-acetone-n-hexane-acetic acid (8:4:0.2:0.5); Color developer: a mixture of 8% vanillin in absolute ethanol solution and sulfuric acid solution (0.5:5); wavelength: λS = 570 nm, λR = 670 nm; scanning method: reflective sawtooth scanning; SX=3. Preparation of the test solution: The pellet was ground into a coarse powder, and about 5 g was accurately weighed, placed in a stopper bottle, and added with 50 ml of methanol, and ultrasonically extracted for 20 minutes, and left overnight. Precisely take 30 ml of supernatant, add 3 times of ethanol, place it to make it completely precipitate, pour off the supernatant, add 10 ml of 10% hydrochloric acid to the precipitate, reflux in a boiling water bath for 2 h, and filter to obtain a precipitate. The precipitate was quantitatively transferred to a 50 ml volumetric flask, dissolved in methanol and diluted to the mark to serve as a test solution. The content of saponins in this product was determined by thin-layer scanning method. As a quantitative analysis, the stability, precision, reproducibility and recovery rate test proved that the method is accurate and reliable, and can play a role in controlling the quality of this product.



    Taking far-offic acid as the reference substance, vanillin-perchloric acid was used as the color developing agent, and the total saponin content of different origins was determined by spectrophotometry at 560 nm. Preparation of the test solution: Take about 1.0g of the crude powder of Polygalaceae, accurately weighed, place it in the Soxhlet extractor, add the appropriate amount of ether, reflux for 4h, take out, remove the ether, add 40mL of methanol, and soak overnight. Add methanol to the appropriate amount, reflux for 4 h, extract the methanol to 10 mL, add 4 times the amount of diethyl ether, leave overnight, filter, and settle the precipitate to a volume of 25 mL with methanol as the test solution.


    Morphological characteristics

    Herbs of annual or perennial, or shrubs or trees, rarely parasitic. Leaves alternate, opposite or sessile. Flowers bisexual, bilaterally symmetrical, white, yellow or purplish red, arranged in racemes, panicles or spikes, axillary or terminal, stalked or absent, sessate or sessate at base; Stored or detached, bracts 5, separated or dilute bases, 3 small outside, 2 large inside, often petal-like, or 5 equal; petal 5, thin all developed, usually only 3, base usually connate, The middle part is often concave, keel-like, with a fringed or butterfly-like appendage on the top of the apex, sparse; stamens 8, or 7, 5, 4, filaments usually form a sheath that opens rearward (tube ), or isolated, anthers basally axillary, apical fissure; discs usually absent, if any, ring or glandular; ovary superior, usually 2-loculed, ovule sessate The chamber has a large number of ovules, style 1, erect or curved, stigma 2, sparse, 1-locate. Fruit or hazelnut, 2 compartments, or samara, nuts, cracked or not, with 2 seeds, or 1 capsule aborted. Seeds ovate, globose or elliptic, yellow-brown, dark brown or black, glabrous or coated, sessile or absent, with or without endosperm.



    13 genera, nearly 1,000 species, are widely distributed throughout the world, especially in tropical and subtropical regions. There are 4 genera and 51 species and 9 varieties in China, which are produced in both north and south, and are the most popular in southwest and south China.

    Growing environment

    Like cool climate, drought tolerance, avoid high temperature, more wild in arid fields, roadsides, hillsides, etc., with good sunny and well-drained sandy cultivation, followed by clay loam and lime loam, clay and low-humidity areas are not suitable plant.


    Main value

    Some species contain acidic saponins - Polygala saponins, hydrolyzable saponins and sugars, for medicinal use, for neurasthenia, palpitations, forgetfulness, insomnia, bronchitis, phlegm and cough; some species for rheumatoid arthritis Some kinds of wood are hard and heavy, the structure is dense, and the planing surface is very smooth, which can be used for interior decoration.


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